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Daily Digest · Tuesday

28 April 2026 Current Affairs for UPSC

5 current affairs published on Tuesday, 28 April 2026

28 April 2026 Current Affairs for UPSC — every Why-in-News article AnantamIAS published on Tuesday, 28 April 2026, broken down with Why in News?, the exact GS paper it feeds, sub-topic mapping, MCQ-ready facts and a UPSC-style practice question. 5 articles in total, covering Polity, Economy, Environment, S&T, IR, Geography, History, Society and Internal Security — the same Why-in-News + GS-paper-mapping + practice-question format the Compass uses across every daily digest on the site.

Daily current affairs for UPSC is where new material enters your prep stream. Read this 28 April 2026 digest end-to-end in 25–35 minutes, attempt the practice question at the foot of each article (it's MCQ for some, 10/15-marker for others), then bookmark the entries that fall inside your active revision window. Everything stays cross-linked: tap any subject pill to jump to that subject's hub, or use the table of contents above to skip straight to a specific story.

Use this page three ways. Read sequentially for a one-sitting scan of everything that mattered on 28 April 2026. Download the 28 April 2026 PDF below for offline study or print revision. Or use the April 2026 Current Affairs compilation to see this day in the month's full context. For the previous day's reading, see 27 April 2026 Current Affairs; the next day's is 29 April 2026 Current Affairs.

Why we publish daily current affairs separately from the monthly compilation: daily is learning, monthly is revision. Use the daily page to add fresh material to your notes the day it breaks; come back to the April 2026 compilation 60 days before Prelims when the noise has settled and only the lasting takeaway is worth re-reading.

India and New Zealand sign Free Trade Agreement

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Why in News?

India and New Zealand have signed a Free Trade Agreement (FTA), marking a significant step in strengthening bilateral economic ties. The FTA is being described as one of India’s fastest concluded bilateral trade deals.

The agreement will require ratification by both countries. India is expected to complete the process through executive approval, while New Zealand will require parliamentary clearance for the agreement to come into force. 

UPSC Relevance: GS-2 International Relations: Trade Agreements; Bilateral Trade
Prelims: India-New Zealand Free Trade Agreement (Key Facts) 

What is Free Trade Agreement? 

  • FTA is an economic arrangement between two or more countries or trading blocs to eliminate or substantially reduce tariff and non-tariff barriers on substantial trade between them.
  • FTAs cover trade in goods (agricultural, pharma, industrial products) or trade in services (banking, construction, trading, etc.). FTAs can also cover other areas such as intellectual property rights (IPRs), cross-border investment, government procurement and competition policy, etc. 

India-New Zealand Free Trade Agreement: Key Highlights

The bilateral trade between India and New Zealand is valued at around $2.4 billion, which includes both goods and services.

1. Trade in Goods: 

  • The FTA will cut or eliminate tariffs on 95% of New Zealand’s exports to India. 
  • The FTA eliminates duty on 100% of Indian exports to New Zealand, covering sectors like textiles, leather, engineering goods and manufacturing products.
  • India has kept several sensitive sectors, including dairy, onions, sugar, spices and edible oils, outside the agreement to safeguard domestic farmers and industry interests.

2. Investment and Trade Expansion: 

  • New Zealand has committed to invest ~$20 billion in India over the next 15 years while easing trade barriers and simplifying regulatory standards.
  • The FTA sets an ambitious target of doubling bilateral trade to around 5 billion dollars over the next five years.

3. Services and Labour Mobility: 

  • The FTA lays out a detailed services framework, where New Zealand commits market access across around 118 sectors, including IT, finance, education, telecom, tourism and professional services. 
  • It establishes a Temporary Employment Entry (TEE) Visa pathway, with a quota of 5,000 visas for skilled Indian nationals, allowing a stay of up to 3 years. The sectors of interest to India include AYUSH practitioners, Yoga Instructors, Indian Chefs, and Music Teachers, as well as IT, Engineering, Healthcare, Education, and Construction.

4. Addressing Non-Tariff Barriers: 

  • Product Specific Rules of Origin (PSRs): FTA provides for a balanced and robust framework of PSRs to effectively prevent circumvention, misuse, or falsification of Rules of Origin criteria.
  • Sanitary and Phytosanitary (SPS) and Technical Barriers: Advances fast-tracking of market access applications on a reciprocal basis, simplifying certification and import permit procedures, and provides for electronic SPS certification.

5. Intellectual Property Rights: 

  • Binding commitment by New Zealand to amend its laws within 18 months to provide EU-level protection for India’s Geographical Indications (GIs).

Once the FTA comes into force, Indian sectors are expected to see expanded market access, including textiles and apparel, engineering goods, leather and footwear, and marine products. New Zealand is likely to register increased exports in horticulture, timber, coal, wool and meat. 

UPSC PYQ 2020

Q. With reference to the international trade of India at present, which of the following statements is/are correct?

1.    India’s merchandise exports are less than its merchandise imports.

2.    India’s imports of iron and steel, chemicals, fertilisers and machinery have decreased in recent years.

3.    India’s exports of services are more than its imports of services.

4.    India suffers from an overall trade/current account deficit.

Select the correct answer using the code given below:

(a)    1 and 2 only

(b)    2 and 4 only

(c)    3 only

(d)    1, 3 and 4 only

Answer: (d) 

UPSC PYQ 2020

Q. Consider the following statements:

1.    The value of Indo-Sri Lanka trade has consistently increased in the last decade. 

2.    “Textile and textile articles” constitute an important item of trade between India and Bangladesh. 

3.    In the last five years, Nepal has been the largest trading partner of India in South Asia. 

Which of the statements given above is/are correct?

(a)     1 and 2 only 

(b)    2 only

(c)    3 only 

(d)    1, 2 and 3

Answer: (b) 

Light Pollution Threatens the World’s Clearest Skies

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Why in News?

Increasing light pollution and industrial expansion are threatening the pristine night skies of the Atacama Desert, one of the world’s most important astronomical regions.

A proposed green energy project near the Paranal Observatory sparked global concern, highlighting gaps in regulatory frameworks for dark-sky preservation.

UPSC Relevance: GS-3 Science and Technology: Astronomy and Space Technology

Prelims: Light Pollution (impacts); Dark Reserves; Extremely Large Telescope; Very Large Telescope; ALMA

What is Light Pollution?

Light pollution refers to excessive artificial light that alters the natural darkness of the night sky. Over 80% of the world’s population lives under light-polluted skies.

What are the Impacts of Light Pollution?

  • Human Health: Disrupts the Circadian Rhythm, affecting melatonin secretion. Lead to sleep disorders, hormonal imbalance, and increased risk of metabolic disorders.
  • Fauna:
    • Disrupts natural behaviour (especially nocturnal species) like navigation, foraging, reproductive cycles and predator-prey interactions. E.g., Sea turtle hatchlings rely on the brightness of the natural horizon to move towards oceans, but artificial beachfront lighting leads them inland, causing fatality. 
    • Disrupts the seasonal migration schedule of migrating birds. 
  • Flora: 
    • Light pollution disrupts Photoperiodism (the response of plants to the relative length of day and night) and thus impacts flowering cycles, dormancy, and seed germination. 
    • Artificial light reduces zooplankton grazing and leads to algal blooms. 
  • Astronomy: Light pollution creates skyglow and reduces the visibility of stars, galaxies, nebulae, etc. It hampers both amateur observation and professional astronomy. 

Astronomical Significance of the Atacama Desert: 

1. Why is Atacama Unique?

  • Climate: Hyperarid (<1 mm of rainfall annually), driest non-polar desert on Earth. 
  • Altitude: Most observatories are located above 3000 m, reducing atmospheric water vapour interference with infrared and millimetre-wave astronomy.
  • Clear Skies: More than 300 cloud-free nights annually, critical for deep-sky and exoplanet research.
  • Light Isolation: Historically isolated from major urban centres.

This has made Atacama an unrivalled hub for world-class astronomy and home to the world’s largest ground-based astronomical projects.

    2. Important Astronomical Projects in the Atacama Desert:

    Photon Valley in Chile is a high-altitude corridor where several observatories operate side by side.

    • Paranal Observatory: Managed by the European Southern Observatory (ESO). It currently houses the Very Large Telescope (VLT) and will operate the future Extremely Large Telescope (ELT). 
    • Extremely Large Telescope: 
      • ELT is under construction atop Cerro Armazones in the Atacama Desert in Chile by ESO. Expected to be completed by 2028. 
      • It has a five-mirror optical design and a primary mirror (M1) that is 39.3 meters in diameter, made of 798 hexagonal segments. 
      • Upon completion, it will be the largest optical/near-infrared telescope in the world. It will have unparalleled light-gathering power (~ 15 times more light than the current leading telescopes). Light-gathering area of nearly 1000 square metres. 
    • Very Large Telescope: One of the world’s most advanced optical telescopes, consisting of four Unit Telescopes (with main mirrors of 8.2m diameter) and four Auxiliary Telescopes (mirrors of 1.8m diameter). The telescopes can work together to form a giant interferometer (ESO Very Large Telescope Interferometer) to achieve much higher angular resolution, allowing astronomers to see finer details of the cosmos.  
    • ALMA (Atacama Large Millimeter /submillimeter Array): The world’s largest ground-based radio telescope array, featuring 66 high-precision antennas located at an altitude of 5000 meters. The project is a massive international partnership (Europe, the US, Canada, Japan, etc.)

    Key Facts: Optical telescopes use a series of mirrors to capture light from space and redirect it to their various instruments. A bigger mirror can collect more light, which means it can both see dimmer things and resolve them in finer detail than a smaller one. 

    Concerns:

    • A proposed green energy complex near Paranal Observatory triggered strong opposition from the scientific community. The project, planned about 10 kilometres from the observatory, raised concerns over light pollution, dust, vibrations and atmospheric instability that could make observations unfeasible.

    This highlights the need to frame robust regulations to strengthen protections for global astronomical zones against light pollution. 

      UPSC PYQ 2016

      Q. With reference to ‘Astrosat’, the astronomical observatory launched by India, which of the following statements is/are correct?

      (1) Other than the USA and Russia, India is the only country to have launched a similar observatory into space.

      (2) Astrosat is a 2000 kg satellite placed in an orbit at 1650 km above the surface of the Earth.

      Select the correct answer using the code given below.

      (a) 1 only

      (b) 2 only

      (c) Both 1 and 2

      (d) Neither 1 nor 2

      Answer: (d) 

      Livelihood of Mumbai fishers at risk as mangroves make way for road

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      Why in News?

      Large-scale diversion of mangrove forests for the Versova–Bhayandar Coastal Road project in Mumbai has raised concerns regarding ecological sustainability and the livelihood security of coastal fishing communities.

      UPSC Relevance

      GS-I: Coastal ecosystems, Mangroves
      GS-II: Governance, Environmental decision-making
      GS-III: Environment, Biodiversity, Sustainable Development, Urbanisation

      Mangroves: Ecological Profile

      Mangroves are salt-tolerant forest ecosystems found in intertidal coastal zones. In India, they are distributed across the eastern and western coasts and island territories.

      They play a crucial role in:

      • Supporting marine biodiversity through nursery and breeding habitats
      • Protecting coastlines from erosion, storm surges, and flooding
      • Acting as significant carbon sinks (blue carbon ecosystems)

      The Issue: Coastal Infrastructure vs Ecological Stability

      The proposed coastal road project aims to improve connectivity and reduce travel time. However, it involves large-scale removal of mangrove cover, leading to a conflict between infrastructure development and environmental sustainability.

      Livelihood Implications

      Fishing communities along Mumbai’s coast depend heavily on mangrove ecosystems. These areas sustain fish populations and provide a stable resource base for small-scale fisheries. Loss of mangroves can therefore:

      • Disrupt traditional occupations
      • Increase economic vulnerability
      • Lead to occupational displacement without adequate alternatives

      Environmental Concerns

      Loss of Ecosystem Services

      Mangroves provide multiple ecosystem services such as coastal protection, biodiversity support, and carbon sequestration. Their removal leads to long-term ecological costs that may outweigh short-term infrastructure gains.

      Limitations of Compensatory Afforestation

      Afforestation efforts often fail to replicate the ecological complexity of natural mangroves due to:

      • Use of limited or non-native species
      • Poor site selection
      • High mortality rates

      Thus, compensatory measures may not adequately substitute the ecological functions lost.

      Increased Climate Vulnerability

      Mumbai is highly vulnerable to sea-level rise and extreme weather events. Reduction in mangrove cover weakens natural coastal defence mechanisms, increasing the risk of flooding and damage.

      Governance and Planning Challenges

      Public Participation Deficit

      Concerns have been raised about inadequate consultation with affected communities, particularly traditional fisher groups. This raises issues of procedural fairness and participatory governance.

      Limitations in Environmental Impact Assessment

      Environmental Impact Assessment processes are often criticised for:

      • Insufficient evaluation of cumulative and long-term impacts
      • Inadequate incorporation of local ecological knowledge

      Urban Planning Concerns

      The prioritisation of road-based infrastructure reflects a broader challenge in urban planning, where ecological considerations and sustainable transport alternatives are not sufficiently integrated.

      Judicial Approach

      Courts have permitted the project subject to compensatory measures such as afforestation. This reflects an attempt to balance development needs with environmental protection, though questions remain regarding the adequacy of such safeguards.

      Way Forward

      1. Integrating Ecosystem-Based Planning

      Urban infrastructure planning must adopt an ecosystem-based approach, wherein natural features such as mangroves are treated as integral components of urban resilience. Spatial planning tools, including coastal zone mapping and vulnerability assessments, should guide project design to minimise ecological disruption.

      2. Strengthening Environmental Impact Assessment Framework

      The EIA process should be made more rigorous by incorporating:

      • Comprehensive cumulative impact assessments
      • Independent expert review mechanisms
      • Greater transparency in data and decision-making

      This would ensure that environmental costs are properly evaluated before project approval.

      3. Ensuring Meaningful Stakeholder Participation

      Consultation processes should go beyond procedural compliance and involve genuine engagement with affected communities. Mechanisms such as social impact assessments and participatory planning can help incorporate local concerns and knowledge into decision-making.

      4. Livelihood Protection and Rehabilitation

      A structured rehabilitation framework is necessary for affected fisher communities, including:

      • Fair and timely compensation
      • Skill development and alternative livelihood opportunities
      • Recognition of traditional rights and dependence on coastal ecosystems

      5. Promoting Sustainable Urban Transport

      Urban transport policy should prioritise:

      • Expansion of public transport systems
      • Multimodal connectivity
      • Reduction of dependence on private vehicles

      This can reduce the need for ecologically disruptive infrastructure projects.

      6. Scientific Mangrove Conservation and Restoration

      Mangrove conservation efforts should focus on:

      • Protection of existing natural ecosystems
      • Restoration using native species and site-specific ecological conditions
      • Long-term monitoring of survival and ecological functionality

      Conclusion

      The conflict between coastal infrastructure development and mangrove conservation highlights the need for a balanced approach that integrates ecological sustainability with developmental objectives. Protecting mangroves is essential not only for environmental reasons but also for safeguarding livelihoods and enhancing urban resilience in the face of climate change.

      Practice Questions

      Prelims

      1. With reference to mangroves in India, consider the following statements:
        1. Mangroves act as breeding grounds for marine organisms.
        2. They are found only along the eastern coast of India.
        3. Mangroves contribute to carbon sequestration.

      Which of the statements given above is/are correct?
      (a) 1 only
      (b) 1 and 3 only
      (c) 2 and 3 only
      (d) 1, 2 and 3

      Mains

      1. Discuss the ecological and economic significance of mangroves in India. Examine the challenges posed by coastal infrastructure projects.
      2. Evaluate the effectiveness of Environmental Impact Assessment in balancing development and environmental conservation in India.
      3. Coastal ecosystems are critical for both environmental sustainability and livelihood security. Analyse with examples.

      Challenges for India’s informal urban workforce 

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      Why in News?

      Recent protests by industrial workers in Noida have highlighted the growing precariousness of India’s urban informal workforce, reflecting deeper structural issues in urbanisation, labour markets, and governance.

      UPSC Relevance

      GS-I: Urbanisation, Social Issues
      GS-II: Governance, Welfare Schemes, Urban Policy
      GS-III: Economy (Labour Market), Inclusive Growth

      Context: Informalisation of Urban Workforce

      India’s labour market is characterised by a high degree of informality:

      • Nearly 90% of total workforce is employed in the informal sector
      • In urban areas, a large proportion of workers are:
        • Casual labourers
        • Self-employed
        • Without written contracts or social security

      This indicates that urban economic growth has not translated into secure and formal employment opportunities.

      Structural Transformation of Urban Economy

      Decline of Industrial Labour

      Historically, cities such as Mumbai and Ahmedabad were centres of organised industrial employment. However:

      • Closure of textile mills and manufacturing units
      • Shift towards service-sector-led growth

      has led to a decline in formal, unionised labour.

      Urbanisation of “Social Reproduction”

      Urban spaces are increasingly shaped by the daily struggle for survival rather than production:

      • Securing housing, water, sanitation
      • Managing household labour and care work

      This reflects a shift where cities are no longer primarily centres of production, but spaces where precarious livelihoods are sustained.

      Changing Role of the State

      From Rights-Based to Market-Oriented Approach

      Economic reforms influenced by neoliberal policies led to:

      • Reduced role of the state in direct service provision
      • Increasing reliance on:
        • Privatisation
        • User-fee-based services

      This has transformed essential services such as:

      • Water
      • Electricity
      • Education

      into market commodities, increasing the burden on the poor.

      Key Challenges Faced by Informal Urban Workers

      1. Employment Insecurity

      • Lack of formal contracts
      • Absence of job security
      • Weak bargaining power

      This results in vulnerability to:

      • Sudden layoffs
      • Wage exploitation

      2. Housing and Land Insecurity

      • Around 40% of urban poor live in informal settlements
      • High expenditure (30–50% of income) on rent

      These settlements often lack:

      • Legal tenure
      • Basic services

      Additionally, eviction and displacement due to urban redevelopment are common.

      3. Exposure to Climate and Environmental Risks

      • Informal urban workers often live in unsafe areas such as low-lying zones, riverbanks, or near drains, which are prone to flooding and other hazards.
      • Their houses are usually poorly built and lack basic infrastructure, making them more vulnerable during heavy rains or heatwaves.
      • Since most depend on daily wages and lack insurance or savings, any disruption caused by climate events directly affects their income and survival.

      4. Rising Cost of Living

      Privatisation and commodification of services have led to:

      • Increased cost of water, electricity, healthcare
      • Reduced affordability for low-income groups

      5. Financial Exclusion

      • Informal workers often lack assets or documents required to access formal banking services. As a result, they depend on local moneylenders who charge high interest rates.
      • This leads to a cycle of debt, making their financial condition unstable and difficult to improve over time.

      6. Weak Collective Representation

      • Decline of trade unions
      • Fragmentation of workforce

      This reduces the ability of workers to:

      • Negotiate wages
      • Demand rights

      What is Urban Intersectionality

      Urban vulnerability is multidimensional, involving:

      • Labour insecurity
      • Housing deprivation
      • Environmental risk
      • Social inequality

      These factors interact, creating a cycle of vulnerability rather than isolated problems.

      Governance Innovations (Emerging Approaches)

      Worker Participation in Urban Governance

      • Experiments like workers’ councils (e.g., Kerala) aim to:
        • Include informal workers in decision-making
        • Recognise them as stakeholders in urban development

      Integration of Informal and Formal Systems

      • Need to connect:
        • Informal workers
        • Trade unions
        • Urban governance institutions

      This can improve representation and policy responsiveness.

      Way Forward

      1. Formalisation with Flexibility

      Policies should aim at gradual formalisation of informal work by:

      • Promoting written contracts
      • Expanding social security coverage
      • Supporting small enterprises

      At the same time, excessive regulation should be avoided to prevent job loss.

      2. Strengthening Social Security Systems

      Universal and portable social protection mechanisms are needed, including:

      • Health insurance
      • Pension schemes
      • Accident insurance

      Schemes such as e-Shram need to be expanded and effectively implemented.

      3. Affordable and Inclusive Urban Housing

      Urban policy must prioritise:

      • Affordable rental housing
      • In-situ slum redevelopment
      • Legal recognition of informal settlements

      This will reduce displacement and improve living conditions.

      4. Reclaiming the Role of the State in Basic Services

      Essential services like water, health, and education should be:

      • Accessible
      • Affordable
      • Treated as public goods

      Reducing excessive reliance on market-based provisioning is crucial.

      5. Strengthening Urban Labour Institutions

      • Revitalise trade unions
      • Create platforms for informal worker representation
      • Encourage collective bargaining mechanisms

      6. Climate-Resilient Urban Planning

      Urban planning must integrate:

      • Risk-sensitive land use
      • Protection of vulnerable settlements
      • Disaster-resilient infrastructure

      This is essential for safeguarding informal workers from climate shocks.

      7. Financial Inclusion

      • Expand access to formal banking and credit
      • Promote microfinance and SHG-based models
      • Reduce dependence on informal lenders

      8. Participatory Urban Governance

      Institutionalise mechanisms such as:

      • Worker councils
      • Community participation forums

      This will ensure that urban policies reflect the needs of the most vulnerable.

      Conclusion

      The challenges of India’s informal urban workforce highlight the limitations of current urbanisation and economic models. Addressing these issues requires a shift towards inclusive, rights-based, and participatory urban development, where economic growth is aligned with social justice and human dignity.

      Practice Questions

      Prelims

      1. With reference to informal sector employment in India, consider the following statements:
        1. It accounts for more than 80% of total employment.
        2. Workers in this sector generally have formal contracts and social security benefits.
        3. Informal employment is limited only to rural areas.

      Which of the statements given above is/are correct?
      (a) 1 only
      (b) 1 and 2 only
      (c) 2 and 3 only
      (d) 1, 2 and 3

      Answer: (a)

      Mains

      1. Discuss the structural challenges faced by the informal urban workforce in India. How can urban governance address these issues?
      2. “Urbanisation in India has led to the growth of informalisation rather than formal employment.” Examine.
      3. Analyse the role of the state in ensuring inclusive urban development in the context of informal labour.

      New Advances in CAR-T Therapy to target Solid Tumours

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      Why in News?

      Sci­ent­ists have developed a highly sens­it­ive receptor that can detect trace amounts of pro­teins on solid tumours, potentially overcoming a major limitation of CAR-T therapy in treating can­cers such as kid­ney or ovarian can­cer. 

      UPSC Relevance: GS-3 Science and Technology: Biology and Biotechnology

      Prelims & Mains: CAR T-cell therapy (Immunology): Applications & Challenges

      What is CAR T-cell therapy?

      • Chimeric Antigen Receptor (CAR) T-cell therapy is a gene therapy where a patient’s own T-cells are genetically modified in a laboratory to identify and destroy cancer cells.
        • T-cells are harvested from the patient’s blood. Researchers genetically modify these cells in the laboratory to express specific proteins on their surface known as chimeric antigen receptors (CAR).
        • These cells are then multiplied in the laboratory and then reinfused into the patient. This genetic modification allows CAR T-cells to effectively bind to cancer cells and destroy them.
      • CAR-T cells directly activate the patient’s immune system against cancer, and thus make cancer treatment more clinically effective than surgery, radiotherapy, and Chemotherapy.

      Current Applications of CAR T-cell therapy:

      • CAR-T therapy is currently approved for several haematological malignancies such as B-cell acute lymphoblastic leukaemia, lymphomas, and multiple myeloma
      • It has shown high response rates (up to ~80-90% in certain cases), particularly in relapsed or refractory cancers, though long-term outcomes vary.

      Limitations  of CAR T-cell therapy:

      • CAR-T therapy is associated with significant side effects, notably:
        • Cytokine Release Syndrome (CRS): widespread activation of the immune system and collateral damage to the body’s normal cells. 
        • Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS): may manifest as fever, breathing difficulty, nausea, confusion, seizures, and speech impairment.
      • The efficacy of CAR T-cell therapy in solid tumours remains limited due to biological barriers. 
      • The complexity of preparing CAR T-cells involves considerable cost and highly skilled human resources for its administration.

      Recent Breakthrough: CAR-T Therapy to target Solid Tumours

      1. The Challenge: Why CAR T-cell therapy fails in Solid Tumours?

      • Antigen Homogeneity in Blood cells: Blood cancers have uniform, abundantly expressed target antigens (such as CD19 and BCMA) on malignant cells, with minimal presence on critical healthy tissue. This enables the genetically engineered T-cells (having artificial CAR receptors) to target the specific cancer antigen.
      • Antigen Heterogeneity in Tumour cells: Tumours are not made of identical cells, and consist of diverse cell populations. Some cells express the target protein that CAR­-T cells detect and destroy. But some invis­ible cells (antigen-negative) sur­vive and allow the can­cer to grow back.

      2. Concept of Pseudo-Heterogeneity:

      • Recent research shows that tumour cells thought to lack the tar­get pro­tein (CD70) actu­ally carry small amounts — too little for cur­rent CAR ­T-cells to detect. The tar­get pro­tein was being sup­pressed by an enzyme called EZH2, which chem­ic­ally mod­i­fies pro­teins around DNA.

      3. The Solution: HIT receptor-equipped T-cells

      • Sci­ent­ists have developed a highly sens­it­ive receptor called HLA­ inde­pend­ent T­-cell (HIT) receptor that can detect trace amounts of pro­teins/ ultra-low antigen levels on solid tumours. 

      The team tested HIT receptor-modified T-cells in xenograft models (where real human tumour tissue was implanted into mice). The results were significant as HIT receptor-equipped T-cells eliminated these previously undetectable cells, achieving complete and lasting tumour eradication across multiple models of kidney, ovarian, and pancreatic cancer.

      This breakthrough over­com­es the major bio­lo­gical hurdle to using CAR T-cell ther­apy against can­cers such as kid­ney or ovarian can­cer.  

      Back to Basics: Key Concepts
      Cancer: Cancer is defined as a group of diseases involving abnormal, uncontrolled cell growth and division. This occurs due to DNA damage or mutations that interfere with the cell’s ability to regulate cell division.
      Immunotherapy: A type of cancer treatment (or biological therapy) that empowers a person’s own immune system to recognise, target, and destroy cancer cells. While chemotherapy and radiotherapy directly kill cancer cells (and some healthy cells too), immunotherapy pushes the body’s own immune system to recognise and kill cancer cells. As immunotherapy is highly targeted, it spares healthy cells
      Antibody: Proteins produced by the immune system to neutralise any foreign substance entering the human body. An antibody attaches itself to an antigen (a foreign substance- usually a disease-causing molecule) and helps the immune system eliminate it from the body.
      T-cells: T-cells are special cells (type of White Blood Cells) whose primary function is to attack and kill pathogens and foreign cells. 

      UPSC PYQ 2022

      Q. Which one of the following statements best describes the role of B-cells and T-cells in the human body?

      (a) They protect the body from environmental allergens.

      (b) They alleviate the body’s pain and inflammation.

      (c) They act as immunosuppressants in the body.

      (d) They protect the body from the diseases caused by pathogens.

      Answer: (d)